This indicates that the loss of IKK2-mediated signalling in only half of the haematopoietic cells may not result in high enough TNF-induced ROS to reach the threshold to initiate a ROS/JNK-positive feedback loop that culminates in increased circulating IL-6, neutrophilia/thrombocytosis and destructive gut inflammation41. The gene discussed is IKBKB; the disease is thrombocytosis disease.