However, in contrast to previous reports stating that IKK2-deleted mice only display mild signs of anaemia and thrombocytosis35,40, our study revealed that animals whose haematopoietic cells had been deleted for IKK2 suffer from severe anaemia and thrombocytosis manifested in significantly decreased erythrocyte counts and significantly elevated platelet counts in comparison to control animals. Here, IKBKB is linked to thrombocytosis disease.