Along with this observation, we also observed significantly lower levels of IL-6, IFN-γ, and CXCL-10 24 h post-infection (Fig. 5j, m, p), IL-17A and TNF-α 4 days post-infection (Fig. 5k, l), and IL-1β, CCL2 and CCL5 7 days post-infection in the lung of IL-38-treated mice (Fig. 5i, n, o), compared with mice without IL-38 administration. The gene discussed is IL1B; the disease is infection.