Moreover, we observed that circulating IL-38 concentrations showed a significantly negative correlation with serum C-reactive protein (CRP) (Fig. 6i), lactate dehydrogenase (LDH) (Fig. 6j), and duration of hospitalization (Fig. 6k) of COVID-19 patients, whereas IL-36α levels were positively correlated with serum CRP (Fig. 6l) and LDH (Fig. 6m), with no significant correlation regarding the duration of hospitalization (Fig. 6n). The gene discussed is CRP; the disease is COVID-19.