NF2 and neurofibromatosis: Neurofibromin 2 [NF2, also known as merlin (moesin-ezrin-radixin-like protein) or schwannomin] is a tumor suppressor protein encoded by the neurofibromatosis type 2 gene NF2. Deletion or loss-of-function mutation of NF2 causes neurofibromatosis type 2, which is a dominant inherited disorder characterized by the development of multiple benign tumors in the nervous system.