Interestingly, when a proved NEPC driver gene SRRM412 was exogenously introduced into PCa cells, tumor cells almost without EHF expression, just like DU145 cells, could acquire a pluripotency gene network that could not be induced by SRRM4 in cells with EHF endogenous expression (Fig. S1b). The gene discussed is EHF; the disease is neoplasm.