We found that EHF expression was significantly lower in t-NEPC tumors than in metastatic CRPC (mCRPC-Adenocarcinoma) and localized AdPC tumors (Michigan 2012 dataset)25; a similar result was also validated in the SU2C/PCF mCRPC dataset (Fig. 1A, left and middle panels)26. This evidence concerns the gene EHF and adenocarcinoma.