Moreover, multivariate Cox regressions demonstrated that the prognostic impact of AGO1 remained significant after adjustment for sex, age, grade, and histology (Table 1, Cox coefficient = −0.231, P = 0.006), suggesting that AGO1 serves as an independent prognostic biomarker in ccRCC. The gene discussed is AGO1; the disease is nonpapillary renal cell carcinoma.