CCL4 and congenital secretory chloride diarrhea 1: CCL4 is metabolized in the liver by cytochrome P450 enzymes and converted to a highly reactive tri-chloromethyl (CCL3●) radical, ultimately leading to hepatotoxic damage, inflammation and fibrosis and most intraperitoneal mice models described only reach a stage of CLD that could be defined as fibrosis or early cirrhosis28.