Again, the yield of CD11c+CD80+, CD11c+CD86+cells did not vary between hepatic NPCs harvested from IDO1−/− fibrotic mice, or WT fibrotic mice and knock out of IDO1 did not influence the expression levels of CD80 and CD86 on hepatic CD11c+DCs during liver fibrosis induced by BDL (Fig. 5A–D). This evidence concerns the gene CD86 and Hepatic fibrosis.