The present work investigated the in vivo role of IDO1 in the pathogenesis of liver fibrosis through assessing the degree of liver fibrosis and maturation status of DCs induced by bile duct ligation (BDL) in wild-type (WT) mice, mice deficient in IDO1 and mice overexpression in IDO1. The gene discussed is IDO1; the disease is Hepatic fibrosis.