In a previous PET study performed with the radiolabelled antagonist [11C]WAY100635, no difference in total 5-HT1A receptor densities was found in schizophrenia patients before and after treatment with the antipsychotic ziprasidone, but there was a significant association between 5-HT1A binding and improvement in negative symptoms51. The gene discussed is HTR1A; the disease is schizophrenia.