After 8 weeks, we found that compared with those of non-diabetic rats, the circadian rhythm gene oscillations of diabetic rats are attenuated in the heart, as manifested by the alteration and attenuated amplitude of the clock output gene Rev-erbα and BMAL1 rhythmicity in STZ-induced diabetes, which is consistent with the results of Young et al.9. The gene discussed is CLOCK; the disease is diabetes mellitus.