CLOCK and heart failure: Recent studies have indicated that the degree of myocardial injury, cardiac function changes, and myocardial remodelling after AMI are closely related to the circadian rhythm of the environment in which they are located; the oscillating amplitude of the circadian clock genes (Rev-erbα, BMAL1) in the ischaemic region exacerbates the development of myocardial infarction and the occurrence of heart failure, suggesting that myocardial damage is related to the circadian rhythm regulated by circadian clock genes11,37,38.