The non-invasive ER+ MCF-7 breast cancer cell line demonstrated increased proliferation response to globular adiponectin.61 By contrast, treatment with full-length108,109 or globular61 adiponectin reduced cell proliferation,61,108,109 and increased apoptosis109 of the invasive ER− MDA-MB-231 breast cancer cell line. The gene discussed is ADIPOQ; the disease is breast carcinoma.