Circulating adiponectin levels are decreased in obesity in both adults and children (young and adolescent).68,69 This is in-part due to adipocytes in the WAT acquiring a pro-inflammatory phenotype, which alters their production of various adipokines including adiponectin.70 Whether adipocytes in BMAT acquire the same obesity-linked phenotype remains unclear. The gene discussed is ADIPOQ; the disease is obesity due to melanocortin 4 receptor deficiency.