Furthermore, under ischemia or hypoxia, the UBS and autophagic activities were increased7,27, which was potentially responsible for the decreased Nav1.5 protein expression5,24 However, the degradation of Nav1.5 could partially but not totally be rescued by the increased FAT10 expression under the conduction of ischemia by antagonizing Nav1.5 ubiquitination, demonstrating a cardioprotective effect of FAT10. This evidence concerns the gene SCN5A and ischemia.