The second analysis (N = 49 BPD+T patients vs. N = 91 BPD-T & CTL) revealed five CpGs with lower methylation levels in the BPD+T group (POU5F1 cg15948871, q value = 3.86 × 10−04; GPR55 cg24915915, q value = 1.15 × 10−02; GGT6 cg04511534, q value = 1.15 × 10−02; TNFRSF13C cg00253346, q value= 1.15 × 10−02; FAM113B cg05478172, q value = 2.61 × 10−02) after adjusting by age and PC (Table 2 and Supplementary Fig. 2). The gene discussed is PCED1B; the disease is Borderline personality disorder.