Epigenome wide comparisons between BPD+T and BPD-T & CTLS revealed significant differences in the level of methylation of CpG islands in five genes, including POU5F1, GPR55, GGT6, TNFRSF13C, and FAM113B, none of them located in the X chromosome. The gene discussed is POU5F1; the disease is Borderline personality disorder.