TBX1 and cancer: M7824 has also been combined with the HPV vaccine PRGN-2009 in phase 1/2 clinical trials for subjects with HPV-associated cancers (NCT04432597) and combined with cancer vaccines that target the EMT driver transcription factor brachyury in phase 1/2 clinical trials for patients with advanced breast cancer (NCT04296942) or metastatic castration-resistant prostate cancer (NCT03493945).291,311,312