It is also worth noting that copy number variants across PIDD1 reported in the DECIPHER database (compiled in ref. 34) include 10 duplications and 1 triplication, 5 of which are de novo, in individuals with ID, global developmental delay, autism, delayed speech and language development, and macrocephaly with postnatal growth retardation. The gene discussed is PIDD1; the disease is Global developmental delay.