PPARG and hepatocellular carcinoma: Several studies have concentrated on the key role of PPARG in cancers with inflammatory regulation.30PPARG was also found to be involved in the regulation of epithelial–mesenchymal transition (EMT).31 However, activated PPARG could reverse the mesenchymal–epithelial phenotype and inhibit EMT.32 In hepatocellular carcinoma and breast cancer, PPARG showed antitumorigenic effects.30 In contrast, PPARG has been reported as an immunomodulator.