ZBTB16 and Familial prostate cancer: As a transcriptional repressor, ZBTB16 has an important role in cell death, differentiation, and tumor progression.25 Downregulation of ZBTB16 was observed in pancreatic cancer and prostate cancer,26,27 and the high expression of ZBTB16 was associated with long-term survival in cancer patients.28,29 In our study, ZBTB16 was reduced, and this reduction might be one of the possible factors associated with pLELC tumorigenesis.