CD274 and nasopharyngeal carcinoma: Our work confirmed previous results reported in other studies indicating that females and nonsmokers are predominantly affected by pLELC and that patients with pLELCs usually show high PD-L1 expression.10 Furthermore, the mutation spectrum of pLELC was found to be distinct from those of other subtypes of NSCLC and EBV+-NPC, with unique FMGs and widespread CNV loss.