ZBTB16 and neoplasm: Using integrated genomic and transcriptome analyses, copy number and expression decreases in five tumor-associated genes (zinc finger and BTB domain-containing 16 (ZBTB16), peroxisome proliferator activated receptor gamma (PPARG), transforming growth factor beta receptor 2 (TGFBR2), early B cell factor 1 (EBF1), and phosphoinositide-3-kinase, regulatory subunit 1 (alpha) (PIK3R1)) were detected in pLELC, especially ZBTB16, PPARG, and TGFBR2 (Fig. 3j).