IL1R1 and Anxiety: Here, we show that mice deficient in inflammasome regulators, including caspase-1 (<i>Casp1</i>), NLR family pyrin domain containing 3 (<i>Nlrp3</i>), IL-1 receptor (<i>Il-1r</i>), and gasdermin D (<i>Gsdmd</i>), exhibit behavior abnormalities characterized by hyperactivity and low anxiety levels.