One study demonstrated that there were three DC subtypes, classified as myeloid, CD4+, and CD8+ DCs, in adipose tissue, and the number of those CD103 DCs decreased under conditions of obesity [131], which played a vital role in the differentiation of regulator T (Treg) cells in small intestinal lamina propria [133]. This evidence concerns the gene ITGAE and obesity due to melanocortin 4 receptor deficiency.