The lack of PPAR-γ in Tregs reduced the number of AT Tregs and specifically altered the transcription characteristics of these cells in obese mice, which indicated that PPAR-γ is the main regulator of AT Treg phenotype, and obesity may affect AT Tregs by regulation of PPAR-γ [165]. Here, PPARG is linked to obesity due to melanocortin 4 receptor deficiency.