An interesting advance was the identification that the transmembrane glycoprotein, CUB-domain containing protein 1 (CDCP1), a driver of migration and invasion in multiple forms of carcinoma, interacts with many members of the ASCL family in breast cancer, and loss-of-function of CDCP1 increases ASCL activity and lipid droplet abundance and reduces fatty acid oxidation and impairs cell migration [158]. Here, CDCP1 is linked to breast cancer.