These specific cancer types are insensitive to pharmacological inhibition of SCD as they upregulate delta-6 desaturase (FADS2) to produce the monounsaturated fatty acyl-CoA sapienyl-CoA (C16:1, n-10) instead of palmitoleoyl-CoA (C16:1, n-9) from palmitoyl-CoA. The gene discussed is FADS2; the disease is cancer.