PEX2 and hepatocellular carcinoma: For example, many studies report reduced peroxisomal protein abundance or enzymatic activities in colon, breast, and hepatocellular carcinoma, whereas others have reported PEX2 mRNA, which encodes peroxisomal biogenesis factor 2 that is required for peroxisome biogenesis, is increased in hepatocellular carcinoma and that knockdown of PEX2 reduced tumor formation (see review [306]).