Several enzymes express TG hydrolase activity, including the adipose triglyceride lipase (ATGL, encoded by PNPLA2) and hormone-sensitive lipase (HSL, encoded by LIPE), as well as carboxylesterase 2 (CES2), alongside its well-described role in drug metabolism [124], and patatin-like phospholipase domain-containing protein 3 (PNPLA3), in human liver [125], but it remains unclear whether CES2 and PNPLA3 participate in TG hydrolysis in cancer cells. The gene discussed is PNPLA3; the disease is cancer.