ALK and anaplastic large cell lymphoma: Likewise, knock-down of the heat shock protein 90 (Hsp90) co-chaperone, Cyclophilin 40 (Cyp40), a JunB transcriptional target in ALK+ ALCL, resulted in reduced viability in multiple ALK+ ALCL cell lines, which could be due in part to a defect in proliferation [97].