Therefore, we speculate that pretreatment with the GDNF gene on AMSCs could better alleviate renal fibrosis by strengthening the ability of AMSCs differentiating into endothelial cells, promoting AMSCs homing to damaged kidney, enhancing angiogenesis through PI3K/AKT/eNOS pathway, and further suppressing oxidative effect and EndMT. This evidence concerns the gene GDNF and renal fibrosis.