TXNIP and obesity due to melanocortin 4 receptor deficiency: cg19693031 in TXNIP showed a strong association with T2D (TXNIP: odds ratio (OR) = 0.56 for a 1 standard deviation increase in methylation, 95% confidence interval (CI) = 0.47–0.69; model 1; Table 3), whereas seven CpG sites across six loci were significantly associated with obesity (smallest p value = 2.8e−7 for a site found in SLC7A11), among them one CpG site in PHGDH. The associations with both T2D and obesity were largely independent of lipid-lowering drug intake.