TP53 and colonic neoplasm: In our study, the IC50 ratio ( IC50 against (p53 − / −) HCT 116 to IC50 against (p53 + / +) HCT 116)) clearly show that p53 knockout HCT116 cells were about four times more sensitive to β-carotene than p53 wild type HCT 116 cells, suggesting the use of this compound against colon cancers cells like HCT 116 bearing p53 mutations.