In consistent with these results, we demonstrated that the recruitment of JMJD3 and NF-κB in the promoter regions of TNF-α, IL-1β, and IL-6 contributed to the upregulation of these pro-inflammatory cytokines via H3K27me3 demethylation, thus promoting inflammatory response in sepsis. The gene discussed is NFKB1; the disease is Sepsis.