HSPA5 and glioblastoma: Through TCGA database, we confirmed that GRP78 mRNA increased with WHO grade and was associated with poor prognosis (Figure S1A, B) and that GRP78 was highest in MES-subtype GBM (Fig. 1a), consistent with GSEA analysis showing that high GRP78 expression was strongly enriched in the MES-subtype gene set (Fig. 1b).