The plasma EBV DNA load was positively correlated with the levels of prothrombin time (PT), thrombin time (TT), a-hydroxybutyrate dehydrogenase (α-HBDH), AST, LDH, creatine kinase (CK), serum creatinine (Scr), blood urea nitrogen (BUN), uric acid (UA), TG, and C-reactive protein (CRP) in EBV-HLH group, and the plasma EBV DNA load was positively correlated with the level of D-Dimer in EBV-IM group (Table 4). The gene discussed is CRP; the disease is hemophagocytic syndrome.