The differentially expressed genes were significantly enriched (hypergeometric test p-value 0.002) for the genes that were differentially expressed between M0 and M6 cells and also model-predicted to be JunD targets (top 500 RPOR scores in down-analysis), further supporting a central role for JunD in driving the transcriptomic changes associated with CRC progression. The gene discussed is JUND; the disease is colorectal carcinoma.