PARP1 and gallbladder carcinoma: Pogostone is another antitumor constituent of patchouli; recent studies [20] revealed that pogostone could inhibit the proliferation and the colony formation of gallbladder carcinoma SGC-996 cells by its capacity to promote the expression of caspase-9, caspase-3, and poly-ADP-ribose polymerase-1 (PARP-1), to increase the Bax/Bcl-2 ratio, and to decrease the expression of cyclin D1, cyclin A, and cyclin B. Taken together, these findings suggest that the antitumor effect of pogostone may be related to the regulation of apoptosis- and cell cycle-regulated proteins.