The combined analysis of PD-1/LAG-3 expression within the stromal tumor compartment and immune phenotype further improved DFS discrimination: “hot” but PD-1− PBTs displayed a significantly better DFS, while “hot” but PD-1+ PBTs showed the same reduced DFS as “cold” PD-1+ or PD-1− tumors (Fig. 2b, c). The gene discussed is PDCD1; the disease is neoplasm.