The mice lacking GAD67 in protein phosphatase 1 regulatory subunit 2 (Ppp1r2)-expressing cells, in which Cre recombinase expression is largely confined to GABA interneurons of the cerebral cortex and the hippocampus, demonstrated the hyper-locomotor activity and anxiety-like behavior in the open-field test [37]. This evidence concerns the gene PPP1R2 and Anxiety.