In addition, Dox-treated Gad1tTA/STOP−tetO mice walked a long time in the wall side and a short time in the center region compared with Dox-treated Gad1+/+ mice (Table 2 and Fig. 5c), indicating that Gad1tTA/STOP−tetO mice exhibited anxiety-like behavior in the open-field test. The gene discussed is GAD1; the disease is Anxiety.