Each 200 g increment in milk per day was related to 10.0 ug/L higher IGF-1 [102]; (2) The casein would contribute to the proliferation of prostate cancer cells including PC3 and LNCaP [103]; (3) Milk would disrupt the p53 and DNA methyltransferase 1 and promote prostate cancer, which were the guardians of the genome [104]; (4) Calcium and phosphorous may decrease concentrations of 1,25(OH)2D, which can inhibit the carcinogenesis of prostate and contribute to apoptosis [101]. The gene discussed is TP53; the disease is Familial prostate cancer.