MPI and disorder of glycogen metabolism: The presence of scattered hepatocytes with foci of glycogenosis in the other may suggest a disturbance of hepatic glycogen breakdown which could stem from excessive mannose-6-phosphate being shunted to fructose-6-phosphate by mannose-phosphate isomerase [21] and feeding into glycolysis, which can inhibit glycogenolysis by ultimately increasing intracellular adenosine triphosphate.