Another interventional study concern 211 prostate cancer patients at newly diagnosed metastatic stage (stage IV) (ClinicalTrials.gov Identifier: NCT01120236), were as a secondary outcome was measured correlation level between miR-141, miR-210, miR-200b and miR-375 as well as PSA level and circulating tumor cells (CTC). Here, PROS1 is linked to prostate cancer.