MAP2K1 and Familial prostate cancer: Chen and Ding et al. have investigated the effect of elevated miRNA expression on PC-3M prostate cancer tumor cells behavior and they found that downregulation of miR-203 was connected with adriamycin (ADM) resistance, thus elevation of miR-203 repress tumor cells proliferation, enhance apoptosis and reduce ADM resistance through influencing on MAPK kinase 1 (MEK1) expression [147].