We also took into account the fact that several cancer-linked Paxillin mutations have been mapped to the intrinsically disordered regions between LDs and not on the motifs themselves, such as P30S, G105A and A127T that lie between LD1 and LD2 and P233L and T255I that lie between LD3 and LD4 [44, 45]. This evidence concerns the gene PXN and cancer.