KDR and diabetic retinopathy: CK30PEG10K compacted DNA nanoparticles have also been tested for suppressing angiogenesis in mice with diabetic retinopathy via delivery of miR200b, a potent inhibitor of VEGFR-2 expression, finding that mice treated with the nanoparticles showed a remarkable decrease in angiogenesis and VEGFR-2 expression which lasted for up to 3 months after a single intravitreal injection [59] (Table 2).