YAP1 and neoplasm: Recently, a systematic profiling of 9,125 tumor samples revealed a widespread dysregulation of Hippo pathway components in multiple human cancer types [31] The Hippo pathway integrates multiple signals to regulate the activity of core transcriptional coactivators YAP/TAZ, which directly or indirectly control multiple cancer hallmarks, including proliferation, survival, evading growth suppressors, reprogramming energy metabolism, angiogenesis, invasion and metastasis, and cancer stem cells, as well as inflammation and immunosuppression [31].