In order to uncover the role of YAP in lung adenocarcinoma, we firstly searched GEO database and performed biological pathway enrichment analysis utilizing GSE64550 datasets, which was designed as RNAseq analysis of HCC364 (lung adenocarcinoma) cells in the context of shRNA knockdown of the gene YAP. The biological pathway enrichment analysis identifies PI3K, mTOR and ErbB related biological pathways (Fig. 2a). This evidence concerns the gene EGFR and lung adenocarcinoma.