In addition, Person correlation analysis revealed that circPIP5K1A and miR-515-5p was negatively correlated in glioma cells (R2 = 0.571, P < 0.001, Fig. 6e), which was the same of TCF12 and miR-515-5p (R2 = 0.463, P < 0.001, Fig. 6f). The gene discussed is TCF12; the disease is central nervous system cancer.