In addition, data from the DAPA-HF [7] and the EMPEROR reduced trial [8] suggest that SGLT2 inhibitors may reduce HF related endpoints and CV death even independent of the presence of diabetes.The underlying mechanisms of these beneficial effects of SGLT2 inhibitors on HF-related events remain unclear but changes in blood pressure, blood glucose, or body weight are unlikely to solely explain the observed results. This evidence concerns the gene SLC5A2 and hydrops fetalis.