Eight genes that were associated with disease progression in an RNA-seq analysis of the metastatic microenvironment from high-grade serous ovarian cancer patient biopsies [53] were in the list of thirty-five genes down-regulated by R-ketorolac when compared to the human genome (ADM, CXCR4, DUSP1, FAM43A, HK2, IGFBP5, NDRG1, and VEGFA). The gene discussed is CXCR4; the disease is ovarian serous adenocarcinoma.