IL4 and fungal infectious disease: Higher IL-4, IL-10, and IL-13 levels were observed to be associated with inadequate IFN-γ production, and otherwise, activation of macrophages dominant to uncontrolled fungal infection [33, 34] as well as Cenci et al. in 1998 reported that mice infected with fungal pathogens are susceptible to produce an IL-10 and IL-4 [35].