The following characteristics differentiate erysipelas from other forms of tissue infections: (1) an acute, warm, slightly painful, bright red erythema with a shiny surface and a sharply defined margin as well as tongue-shaped processes, usually located a few centimeters away from the entry site; (2) a systemic inflammatory response immediately from the onset, marked by fever or at least shivering and rarely chills; and (3) increased erythrocyte sedimentation rate (ESR), increased C-reactive protein (CRP) level, and/or neutrophilia [3]. This evidence concerns the gene CRP and erysipelas.