Based on our findings there were notable clinical differences between PLA2R positive patients and LN-V patients with PLA2R patients having 1.7 fold heavier proteinuria and more than 2-fold higher total serum cholesterol levels than lupus MN patients; as is typical for the demographic epidemiology of lupus, there was a female predisposition for lupus. This evidence concerns the gene PLA2R1 and systemic lupus erythematosus.