PLA2R1 and nephrotic syndrome: Given that MGN (both primary and secondary types due to hepatitis B and lupus nephritis) has been shown to be a common cause of nephrotic syndrome in adults in African studies of kidney biopsies, differentiating primary from secondary type is important for making therapeutic decisions.[3, 6, 14] There are currently no studies in Africa assessing the utility of serum or glomerular PLA2R or THSD7A for accurately identifying patients with PMN.