Significant intergroup differences were observed regarding factors such as sex, alcohol use, tumor size ≥ 5 cm, AFP level ≥ 200 ng/mL, operative margin > 1 cm, major hepatectomy, microvascular invasion, macrovascular invasion, AJCC stage I–II, recurrence, recurrence per 100 person-years, mortality, mortality per 100 person-years, and median follow-up time. The gene discussed is AFP; the disease is neoplasm.