However, the proportion of patients with diabetes mellitus, hypercholesteremia, hyperuricemia, multivessel artery lesions, two target lesions, target lesion at LCX, ACEIs/ARBs, and the level of FBG, IRI, Scr, LDL-C, HsCRP, NT-proBNP, length of target lesion, length of stent were increased, while the level of HDL-C was decreased in 2-year ISR patients compared with 2-year non-ISR patients (all P < 0.05) (Table 1). This evidence concerns the gene NPPB and hyperuricemia.