In addition, the results exhibited that diabetes mellitus, LDL-C, HsCRP, two target lesions and length of target lesion were also independent factors for greater 2-year ISR risk in CHD patients underwent PCI with DES, which was in consistence with the previous evidence about the risk factors for restenosis after implantation of DES [3, 5, 29, 30]. This evidence concerns the gene COG2 and coronary artery disorder.