The aforementioned data suggests the contribution of FGF-23 on development of cardiovascular injury and coronary stenosis, therefore, we hypothesized that FGF-23 might be also correlated with ISR risk in CHD patients treated by PCI with DES, however, study related to the predictive potential of FGF-23 in ISR risk has not been conducted yet. The gene discussed is FGF23; the disease is coronary stenosis.