FGF-23 is a bone-derived hormone in response to the increment of circulating phosphate and calcitriol levels, and its implication in the pathogenesis of CKD has been revealed that increased FGF-23 disrupts the bone-kidney-parathyroid hormone balance, which promotes the generation of hyperphosphatemia with the progression of CKD [18]. The gene discussed is FGF23; the disease is chronic kidney disease.