Further forward stepwise multivariate logistic regression exhibited that FGF-23 (OR = 1.005, P = 0.001), diabetes mellitus (OR = 23.654, P < 0.001), LDL-C (OR = 4.458, P = 0.002), HsCRP (OR = 1.261, P < 0.001), two target lesions (OR = 6.305, P = 0.002), length of target lesion (OR = 1.128, P = 0.001) were independent predictive factors for increased 2-year ISR in CHD patients. Here, FGF23 is linked to coronary artery disorder.