NKX2-5 and cardiac arrhythmia: Although some reported arrhythmias and conduction disorders may be associated with atrial septal defects [38], the reason is unknown and some transcriptional factors genes mutations were related to the ASD family with arrhythmias [39], one possible evidence shown by computationally Mattapally et al. [40], where they established that NKX2.5 cooperativity with GATA4 facilitates its activating and repressing functions [41–43].