INHBE and spontaneous abortion: Case 7665 has a duplication of INHBB, which encodes a subunit for the activin and inhibin proteins that play important roles in trophoblast growth and invasion (Bearfield et al. 2005; Li et al. 2014), and altered mRNA or protein levels of these compounds are associated with miscarriage, severe PE, and FGR (Wijayarathna and Kretser 2016).