The results showed that IL-18-137G/C polymorphisms in the IL-18 gene were associated with increased TB risk in china when comparing the G allele vs. C allele (OR = 1.49, 95% CI = 1.21–1.84, P = 0.0002, GG vs. GC+CC, P = 0.0003) [32]. This evidence concerns the gene IL18 and tuberculosis.