We found that all mice succumbed to lethal virus challenge, regardless of the type of antibody administered, by Day 8 post-virus infection; there were no significant differences in weight loss (Fig 4F) or survival (Fig 4G) between mice receiving PBS, IgG1 N297A, or monomeric or polymeric IgA1/IgA2m2 FI6 antibodies. The gene discussed is IGHA1; the disease is viral infectious disease.