We have previously identified the protein kinase PKCδ (PRKCD), phosphorylated on tyrosine 374 (Y374), as a substrate of the nonreceptor tyrosine phosphatase and tumor suppressor PTPN14 (Pez or PTPD2) and have shown that reduced expression or catalytic activity of PTPN14 leads to increased cell surface expression of the RTKs vascular endothelial growth factor receptor 3 (VEGFR3 or FLT4) in primary lymphatic endothelial cells and epidermal growth factor receptor (EGFR) in breast cancer cells (Belle et al., 2015). The gene discussed is PRKCD; the disease is breast cancer.