The tyrosine phosphatase PTPN14 has been shown to limit levels of EGFR on the surface of breast cancer cells, potentially through dephosphorylation of the phospho-Y374 form of PKCδ (henceforth designated pY374-PKCδ; Belle et al., 2015), but how this affects intracellular trafficking of the receptor has not been determined. The gene discussed is EGFR; the disease is breast carcinoma.