Moreover, consistent with previous reports showing the recruitment of TRAF3 to MAVS as an important process leading to downstream signaling, the silencing of TFG also blunted the activating transautophosphorylation of TBK1 on Ser172 (p-TBK1 Ser172) normally observed upon viral infection (Fig 4B). This evidence concerns the gene TBK1 and viral infectious disease.