GRN and metastatic neoplasm: Multivariate analysis in non-metastatic disease showed that high PGRN expression (hazard ratio [HR] 51.4, 95% CI 3.2–821.9, P = 0.005) and old age (>60 years; HR 5.7, 95% CI 1.01–31.7, P = 0.049) were independent prognostic factors associated with poor RFS (Table 4).