The levels of TNF-alpha (p<0.0001; Fig 4B), IL-6 (p = 0.027; Fig 4D), IL1-beta (p<0.0001; Fig 4F) and MCP-1 (p<0.0001; Fig 4H) in the tumor microenvironment were positively correlated with OSCC volume. This evidence concerns the gene IL6 and neoplasm.